| Safety data sheet |
| According to EC Directive 91/155/EEC |
|
|
| 1. Identification of the substance/preparation and of the company/undertaking |
| Identification of the product | ||
| Catalogue No.: | 100209 | |
| Product name: | Acrylamide for electrophoresis special quality for molecular biology | |
| Manufacturer/supplier identification | ||
| Company: |
Merck Ltd. 9th Floor, Monterey Tower, 2170 New Petchburi Road, Bangkapi, Huaykwang, Bangkok 10320 Tel: (662) 308 - 0218 |
|
| 2. Composition/information on ingredients |
| CAS-No.: | 79-06-1 | EC-Index-No.: | 616-003-00-0 | ||
| Molar mass: | 71.08 | EINECS-No.: | 201-173-7 | ||
| Molecular formula: | C3H5NO | ||||
| 3. Hazards identification |
| May cause cancer. May cause heritable genetic damage. Also toxic in contact with skin and if swallowed. Also toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. |
| 4. First aid measures |
|
After inhalation: fresh air. Summon doctor. After skin contact: wash off with plenty of water. Remove contaminated clothing. After eye contact: rinse out with plenty of water for at least 10 minutes with the eyelid held wide open. Immediately summon eye specialist. After swallowing: make victim drink plenty of water, induce vomiting. Immediately summon doctor. |
| 5. Fire-fighting measures |
| Suitable extinguishing media: |
| Water, foam. |
|
Extinguishing media not to be used: |
| CO2 |
|
Special risks: |
| Combustible. Formation of hazardous combustion gases or vapours possible in event of fire. Danger of dust explosion. The following may develop in event of fire: carbon monoxide , ammonia , nitrous gases |
| 6. Accidental release measures |
|
Person-related precautionary measures: Avoid generation and inhalation of dusts in all circumstances. Procedures for cleaning / absorption: Take up carefully. Forward for disposal. Clean up affected area. |
| 7. Handling and storage |
| Handling: |
| No further requirements. |
| Storage: |
| Tightly closed. In a well-ventilated place. Cool (below +15°C). Accessible only for authorized persons. |
| 8. Exposure controls/personal protection |
| Personal protective equipment: | |
| Respiratory protection: | required when dusts are generated. |
| Eye protection: | required |
| Hand protection: |
required Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier. |
| Industrial hygiene: | Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. Under no circumstances eat or drink at workplace. Avoid generation of dusts. |
| 9. Physical and chemical properties |
| Form: | solid | |||
| Colour: | colourless | |||
| Odour: | almost odourless | |||
| pH value | ||||
| at 50 g/l water | (20 °C) | 5.5 - 7.5 | ||
| Melting temperature | 82 - 85 °C | |||
| Boiling temperature | 125 °C | |||
| Ignition temperature | not available | |||
| Flash point | not available | |||
| Explosion limits | lower | not available | ||
| upper | not available | |||
| Density | (30 °C) | 1.12 g/cm3 | ||
| Solubility in | water | (20 °C) | soluble | |
| Thermal decomposition | > 150 °C |
| 10. Stability and reactivity |
| Conditions to be avoided |
| no information available |
| Substances to be avoided |
| acids , alkalis , oxidizing agent , reducing agents |
| Hazardous decomposition products |
| in the event of fire : carbon monoxide , ammonia , nitrous gases |
| Further information |
| tends to polymerize at temperatures exceeding 100°C light-sensitive ( polymerization ) |
| 11. Toxicological information |
| Acute toxicity |
|
LD50 (oral, rat): 124 mg/kg ; LDLo (dermal, rabbit): 1000 mg/kg |
| Subacute to chronic toxicity |
|
Animal experiments performed under conditions comparable with the workplace situation have shown the substance to be carcinogenic. A mutagenic effect has been demonstrated in animal studies on mammals, justifying the assumption that exposure of humans to the substance produces hereditary damage. |
| Further toxicological information |
|
After inhalation: Irritations of the mucous membranes, coughing, and dyspnoea. CNS disorders , ataxia (impaired locomotor coordination) Danger of skin absorption. After eye contact: Irritations. After skin contact: Severe irritations. After swallowing: irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract. |
| 12. Ecological information |
|
Ecotoxic effects: Degradability: BOD5: 0.97 g/g Biological effects: C.auratus LC50: 460 mg/l /24 h ; C.auratus LC50: 160 mg/l /96 h Further ecologic data: Do not allow to enter waters, waste water, or soil! |
| 13. Disposal considerations |
| Product: |
| There are no uniform EC Regulations for the disposal of chemicals or residues. Chemical residues generally count as special waste. The disposal of the latter is regulated in the EC member countries through corresponding laws and regulations. We recommend that you contact either the authorities in charge or approved waste disposal companies which will advise you on how to dispose of special waste. |
| Packaging: |
| Disposal in compliance with official regulations. Handle contaminated packaging in the same way as the substance itself. If not officially specified differently, non-contaminated packaging may be treated like household waste or recycled. |
| 14. Transport information |
| Transport over land ADR/RID and GGVS/GGVE (Germany) | ||||
| GGVS/GGVE class: | 6.1 | Number and letter: | 12c | |
| ADR/RID class: | 6.1 | Number and letter: | 12c | |
| Name of material: | 2074 ACRYLAMID | |||
| River transport ADN/ADNR | |||
| not examined | |||
| Sea transport IMDG | ||||||
| IMDG class: | 6.1 | UN-No.: | 2074 | Packaging group: | III | |
| Ems: | 6.1-04 | MFAG: | 323 | |||
| Correct technical name: | ACRYLAMIDE, SOLID | |||||
| Air transport ICAO-TI and IATA-DGR | |||||
| ICAO/IATA class: | 6.1 | UN/ID-No.: | 2074 | Packaging group: | III |
| Correct technical name: | ACRYLAMIDE | ||||
| The transport regulations are cited according to international regulations and in the form applicable in Germany (GGVS/GGVE). Possible national deviations in other countries are not considered. |
| 15. Regulatory information |
| Labelling according to EC Directives | ||
| Symbol: | T | Toxic immediately and show this container or label. |
| R-phrases: | R 45-46-E24/25-E48/23/24/25 | May cause cancer. May cause heritable genetic damage. Also toxic in contact with skin and if swallowed. Also toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. |
| S-phrases: | S 53-45 | Avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
| EC-No.: | 201-173-7 | EC label |
| German regulations | ||
| Water pollution class | 3 | (highly polluting substance) |
| 16. Other information |
| Reason for alteration |
|
Change in the chapter on toxicology. General update. |
