| Safety data sheet |
| According to EC Directive 91/155/EEC |
|
|
| 1. Identification of the substance/preparation and of the company/undertaking |
| Identification of the product | ||
| Catalogue No.: | 101768 | |
| Product name: | Benzene for chromatography LiChrosolv® | |
| Manufacturer/supplier identification | ||
| Company: |
Merck Ltd. 9th Floor, Monterey Tower, 2170 New Petchburi Road, Bangkapi, Huaykwang, Bangkok 10320 Tel: (662) 308 - 0218 |
|
| 2. Composition/information on ingredients |
| Synonyms |
| Cyclohexatriene |
| CAS-No.: | 71-43-2 | EC-Index-No.: | 601-020-00-8 | ||
| Molar mass: | 78.11 | EINECS-No.: | 200-753-7 | ||
| Molecular formula: | C6H6 | ||||
| 3. Hazards identification |
| May cause cancer. Highly flammable. Also toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. |
| 4. First aid measures |
|
After inhalation: fresh air. If necessary, apply mouth-to-mouth resuscitation or mechanical ventilation. After skin contact: wash off with plenty of water. Remove contaminated clothing. After eye contact: rinse out with plenty of water with the eyelid held wide open. Summon eye specialist. After swallowing: Avoid vomiting. Risk of aspiration! Laxative: Paraffin oil (3 ml/kg). Sodium sulfate (1 tablespoon/1/4 l water). Summon doctor. Gastric lavage: only in cases of emergency and with utmost caution. Keep airways free. |
| 5. Fire-fighting measures |
| Suitable extinguishing media: |
| Powder, foam. Fire extinguisher: powder , carbon dioxide |
|
Special risks: |
| Combustible. Vapours heavier than air. Formation of explosible mixtures possible with air. Keep away from sources of ignition. Take measures to prevent electrostatic charging. Development of hazardous combustion gases or vapours possible in the event of fire. |
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Special protective equipment for fire fighting: |
| Do not stay in dangerous zone without suitable chemical protection clothing and self-contained breathing apparatus. |
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Other information: |
| Prevent fire-fighting water from entering surface water or groundwater. |
| 6. Accidental release measures |
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Person-related precautionary measures: Do not inhale vapours/aerosols. Avoid substance contact. Procedures for cleaning / absorption: Take up with liquid-absorbent material (e.g. Chemizorb® ). Forward for disposal. Clean up affected area. Environmental-protection measures: Do not allow to enter sewerage system; risk of explosion! |
| 7. Handling and storage |
| Handling: |
| Take measures to prevent electrostatic charging. |
| Storage: |
| Tightly closed. Protected from light. In a well-ventilated place. Keep away from sources of ignition and heat. At +15°C to +25°C. Accessible only for authorized persons. |
| 8. Exposure controls/personal protection |
| EC-value/cat. | |
| Benzene | 1 ml/m3 or 3.25 mg/m3 |
| Personal protective equipment: | |
| Respiratory protection: | required when vapours/aerosols are generated. Filter A (acc. to DIN 3181) for vapours of organic compounds , Respirator. |
| Eye protection: | required |
| Hand protection: |
required Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier. |
| Other protective equipment: | Fire-resistant protective clothing. |
| Industrial hygiene: | Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. Under no circumstances eat or drink at workplace. |
| 9. Physical and chemical properties |
| Form: | liquid | |||
| Colour: | colourless | |||
| Odour: | characteristic | |||
| pH value | not available | |||
| Viscosity | dynamic | (20 °C) | 0.66 mPa*s | |
| Melting temperature | 5 °C | |||
| Boiling temperature | 80 °C | |||
| Ignition temperature | 555 °C | |||
| Flash point | -11 °C | |||
| Explosion limits | lower | 1.2 Vol% | ||
| upper | 8.0 Vol% | |||
| Vapour pressure | (20 °C) | 100 mbar | ||
| Density | (20 °C) | 0.88 g/cm3 | ||
| Solubility in | water | (20 °C) | 1.8 g/l | |
| log P(oct): | 2.13 |
| 10. Stability and reactivity |
| Conditions to be avoided |
| Heating. |
| Substances to be avoided |
| mineral acids , sulfur , halogens , halogen-halogen compounds , oxidizing agent , (i.a. nitric acid , ozone , peroxi compounds , oxyhalogenic compounds , CrO3 ) , halogenated hydrocarbons (in the presence of: light metals ) |
| Hazardous decomposition products |
| not known to date |
| Further information |
|
steam-volatile ; incompatible with rubber , various plastics Explosible with air in a vaporous/gaseous state. |
| 11. Toxicological information |
| Acute toxicity |
|
LD50 (oral, rat): 930 mg/kg LC50 (inhalation, rat): 10000 ppm(V) /7 h The literature data available to us do not conform with the labelling prescribed by the EC. The EC has dossiers of the manufacturers which have not been published. |
| Subacute to chronic toxicity |
| Experience has shown this substance to be carcinogenic in man. |
| Further toxicological information |
|
After skin contact: irritant effect Danger of skin absorption. Degreasing effect on the skin, possibly followed by secondary inflammation. After eye contact: mucosal irritations Swallowing causes nausea and vomiting. Risk of aspiration upon vomiting. After absorption: headache , dizziness , cardiac dysrhythmia , drop in blood pressure , dyspnoea , agitation, spasms , narcosis , cardiovascular failure , respiratory paralysis , death |
| Further data |
| The product should be handled with the care usual when dealing with chemicals. |
| 12. Ecological information |
|
Biologic degradation: Readily biodegradable (reduction: DOC >70 %; BOD >60 %; BOD5 to COD >50 %). Behavior in environmental compartments: Distribution: log P(oct):: 2.13 ; Evaluation number (FRG) (bacteria): 3.7 - 4.0 ; Evaluation number (FRG) (fish): 4.2 - 4.5 ; Evaluation number (FRG) (mammal): 1.0 ; Ecotoxic effects: Biological effects: Toxic for aquatic organisms Toxic effect on fish and plankton. Change in the flavour characteristics of fish protein. Endangers drinking-water supplies if allowed to enter soil or water. Risk of formation of toxic and explosive mixtures with air above water surface. May cause long-term adverse effects in the aquatic environment. Fish toxicity: L.idus LC50: 33 mg/l ; C.auratus LC50: 46 mg/l /24 h ; Bacterial toxicity: Ps.pudita EC0: 92 mg/l ; Daphnia toxicity: Daphnia magna LC50: 1130 mg/l ; Algeal toxicity: Sc.quadricauda EC0: > 1400 mg/l ; aquatic organisms LC50: 10 mg/l /96 h Further ecologic data: Degradability: BOD 10 % of ThOD /5 d ; COD 19 % of ThOD ; ThOD: 3.10 g/g ; Do not allow to enter waters, waste water, or soil! |
| 13. Disposal considerations |
| Product: |
| There are no uniform EC Regulations for the disposal of chemicals or residues. Chemical residues generally count as special waste. The disposal of the latter is regulated in the EC member countries through corresponding laws and regulations. We recommend that you contact either the authorities in charge or approved waste disposal companies which will advise you on how to dispose of special waste. |
| Packaging: |
| Disposal in compliance with official regulations. Handle contaminated packaging in the same way as the substance itself. If not officially specified differently, non-contaminated packaging may be treated like household waste or recycled. |
| 14. Transport information |
| Transport over land ADR/RID and GGVS/GGVE (Germany) | ||||
| GGVS/GGVE class: | 3 | Number and letter: | 3b | |
| ADR/RID class: | 3 | Number and letter: | 3b | |
| Name of material: | 1114 BENZEN | |||
| River transport ADN/ADNR | |||
| not examined | |||
| Sea transport IMDG | ||||||
| IMDG class: | 3.2 | UN-No.: | 1114 | Packaging group: | II | |
| Ems: | 3-03 | MFAG: | 312 | |||
| Correct technical name: | BENZENE | |||||
| Air transport ICAO-TI and IATA-DGR | |||||
| ICAO/IATA class: | 3 | UN/ID-No.: | 1114 | Packaging group: | II |
| Correct technical name: | BENZENE | ||||
| The transport regulations are cited according to international regulations and in the form applicable in Germany (GGVS/GGVE). Possible national deviations in other countries are not considered. |
| 15. Regulatory information |
| Labelling according to EC Directives | ||
| Symbol: | F | Highly flammable immediately and show this container or label. |
| T | Toxic immediately and show this container or label. | |
| R-phrases: | R 45-11-E48/23/24/25 | May cause cancer. Highly flammable. Also toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. |
| S-phrases: | S 53-45 | Avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
| EC-No.: | 200-753-7 | EC label |
| German regulations | ||
| Water pollution class | 3 | (highly polluting substance) |
| 16. Other information |
| Reason for alteration |
|
See chapter 8 General update. |
