| Safety data sheet |
| According to EC Directive 91/155/EEC |
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| 1. Identification of the substance/preparation and of the company/undertaking |
| Identification of the product | ||
| Catalogue No.: | 159129 | |
| Product name: | Chloroform Reag. Ph Eur | |
| Manufacturer/supplier identification | ||
| Company: |
Merck Ltd. 9th Floor, Monterey Tower, 2170 New Petchburi Road, Bangkapi, Huaykwang, Bangkok 10320 Tel: (662) 308 - 0218 |
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| 2. Composition/information on ingredients |
| Synonyms |
| Trichloromethane ; Formyl trichloride |
| CAS-No.: | 67-66-3 | EC-Index-No.: | 602-006-00-4 | ||
| Molar mass: | 119.38 | EINECS-No.: | 200-663-8 | ||
| Molecular formula: | CHCl3 | ||||
| 3. Hazards identification |
| Harmful if swallowed. Irritating to skin. Possible risks of irreversible effects. Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed. |
| 4. First aid measures |
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After inhalation: fresh air. If necessary, apply mouth-to-mouth resuscitation or mechanical ventilation. Keep airways free. After skin contact: wash off with plenty of water. Remove contaminated clothing. After eye contact: rinse out with plenty of water for at least 10 minutes with the eyelid held wide open. Summon eye specialist. After swallowing: Caution if victim vomits. Risk of aspiration! Laxative: Paraffin oil (3 ml/kg). Sodium sulfate (1 tablespoon/1/4 l water). Subsequently administer: activated charcoal (20 - 40 g in 10% slurry). Summon doctor. No castor oil. No milk. No alcohol. Instructions for the doctor: Gastric lavage. |
| 5. Fire-fighting measures |
| Suitable extinguishing media: |
| In adaption to materials stored in the immediate neighbourhood. |
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Special risks: |
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Development of hazardous combustion gases or vapours possible in the event of fire. The following may develop in event of fire: hydrochloric acid , chlorine , phosgene |
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Other information: |
| Non-combustible. |
| 6. Accidental release measures |
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Person-related precautionary measures: Do not inhale vapours/aerosols. Avoid substance contact. Procedures for cleaning / absorption: Take up with liquid-absorbent material (e.g. Chemizorb® ). Forward for disposal. Allow remainder to evaporate. Environmental-protection measures: Do not allow to enter sewerage system. |
| 7. Handling and storage |
| Handling: |
| No further requirements. |
| Storage: |
| Tightly closed. In a well-ventilated place. Accessible only for authorized persons. At +15°C to +25°C. |
| 8. Exposure controls/personal protection |
| Specific control parameter | ||
| MAK Germany (max. workplace conc.) | ||
| Chloroform | 10 ml/m3 or 50 mg/m3 | |
| Personal protective equipment: | |
| Respiratory protection: | required when vapours/aerosols are generated. Filter A (acc. to DIN 3181) for vapours of organic compounds |
| Eye protection: | required |
| Hand protection: |
required Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier. |
| Industrial hygiene: | Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. |
| 9. Physical and chemical properties |
| Form: | liquid | |||
| Colour: | colourless | |||
| Odour: | characteristic | |||
| pH value | not available | |||
| Viscosity | dynamic | (20 °C) | 0.56 mPa*s | |
| Melting temperature | -63 °C | |||
| Boiling temperature | 61 °C | |||
| Ignition temperature | not available | |||
| Flash point | not available | |||
| Explosion limits | lower | not available | ||
| upper | not available | |||
| Vapour pressure | (20 °C) | 213 mbar | ||
| Density | (20 °C) | 1.47 g/cm3 | ||
| Solubility in | water | (20 °C) | 8 g/l | |
| log P(oct): | 1.97 |
| 10. Stability and reactivity |
| Conditions to be avoided |
| Strong heating. |
| Substances to be avoided |
| alkali metals , alkaline earth metals , metals ( in powder form ) , peroxi compounds , fluorine , alcoholates , strong alkalis , ketones / alkalis , alkali hydroxides / alcohols , organic nitro compounds , alkali amides , oxygen , oxygen / alkalis , nitrogen oxides , nonmetallic hydrogen compounds , bis(dimethylamino)dimethyl tin |
| Hazardous decomposition products |
| hydrochloric acid , phosgene , chlorine |
| Further information |
| heat-sensitive , light-sensitive |
| 11. Toxicological information |
| Acute toxicity |
|
LD50 (oral, rat): 908 mg/kg LC50 (inhalation, rat): 75 mg/l /1 h LDLo (oral, human): 140 mg/kg LCLo (inhalation, human): 25000 ppm(V) /5 min The literature data available to us do not conform with the labelling prescribed by the EC. The EC has dossiers of the manufacturers which have not been published. |
| Subacute to chronic toxicity |
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The carcinogenic potential requires further clarification. The information available to us suggests that the risk of an embryotoxic effect must be considered probable. Pregnant women should not be exposed to the product. |
| Further toxicological information |
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After inhalation of vapours: coughing , dyspnoea After absorption: agitation, spasms , narcosis After skin contact: irritant effect After eye contact: irritant effect ( mucosal irritations ) After swallowing: nausea , vomiting Systemic effects: After long-term exposure to the chemical: drop in blood pressure , headache , ataxia (impaired locomotor coordination) , gastrointestinal complaints , cardiovascular disorders |
| Further data |
| Cannot be excluded: Damage of: liver , kidneys |
| 12. Ecological information |
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Biologic degradation: Not degradable in water. Behavior in environmental compartments: Distribution: log P(oct):: 1.97 ; Low bioaccumulation potential. Evaluation number (FRG) (bacteria): 3.9 ; Evaluation number (FRG) (fish): 3.9 - 4.7 ; Evaluation number (FRG) (mammal): 3 ; Ecotoxic effects: Biological effects: Toxic for aquatic organisms Endangers drinking-water supplies if allowed to enter soil and/or waters in large quantities. Fish toxicity: L.idus LC50: 162 mg/l ; L.idus LC100: 176 mg/l ; Bacterial toxicity: Ps.pudita EC0: 125 mg/l ; Algeal toxicity: M.aeruginosa EC0: 185 mg/l ; Sc.quadricauda EC0: 1100 mg/l ; Protozoa : E.sulcatum EC0: > 6560 mg/l ; aquatic organisms LC50: 10 mg/l /96 h ; Further ecologic data: BOD5: 0.02 g/g ; ThOD: 1346 mg/g ; Do not allow to enter waters, waste water, or soil! |
| 13. Disposal considerations |
| Product: |
| There are no uniform EC Regulations for the disposal of chemicals or residues. Chemical residues generally count as special waste. The disposal of the latter is regulated in the EC member countries through corresponding laws and regulations. We recommend that you contact either the authorities in charge or approved waste disposal companies which will advise you on how to dispose of special waste. |
| Packaging: |
| Disposal in compliance with official regulations. Handle contaminated packaging in the same way as the substance itself. If not officially specified differently, non-contaminated packaging may be treated like household waste or recycled. |
| 14. Transport information |
| Transport over land ADR/RID and GGVS/GGVE (Germany) | ||||
| GGVS/GGVE class: | 6.1 | Number and letter: | 15c | |
| ADR/RID class: | 6.1 | Number and letter: | 15c | |
| Name of material: | 1888 CHLOROFORM | |||
| River transport ADN/ADNR | |||
| not examined | |||
| Sea transport IMDG | ||||||
| IMDG class: | 6.1 | UN-No.: | 1888 | Packaging group: | III | |
| Ems: | 6.1-02 | MFAG: | 340 | |||
| Correct technical name: | CHLOROFORM | |||||
| Air transport ICAO-TI and IATA-DGR | |||||
| ICAO/IATA class: | 6.1 | UN/ID-No.: | 1888 | Packaging group: | III |
| Correct technical name: | CHLOROFORM | ||||
| The transport regulations are cited according to international regulations and in the form applicable in Germany (GGVS/GGVE). Possible national deviations in other countries are not considered. |
| 15. Regulatory information |
| Labelling according to EC Directives | ||
| Symbol: | Xn | Harmful immediately and show this container or label. |
| R-phrases: | R 22-38-40-48/20/22 | Harmful if swallowed. Irritating to skin. Possible risks of irreversible effects. Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed. |
| S-phrases: | S 36/37 | Wear suitable protective clothing and gloves. |
| EC-No.: | 200-663-8 | EC label |
| German regulations | ||
| Water pollution class | 3 | (highly polluting substance) |
| 16. Other information |
| Reason for alteration |
| ***Specific control parameter. |
