| Safety data sheet |
| According to EC Directive 91/155/EEC |
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| 1. Identification of the substance/preparation and of the company/undertaking |
| Identification of the product | ||
| Catalogue No.: | 112492 | |
| Product name: | 1,2-Propylene oxide for electron microscopy | |
| Manufacturer/supplier identification | ||
| Company: |
Merck Ltd. 9th Floor, Monterey Tower, 2170 New Petchburi Road, Bangkapi, Huaykwang, Bangkok 10320 Tel: (662) 308 - 0218 |
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| 2. Composition/information on ingredients |
| Synonyms |
| 1,2-Epoxypropane ; Methyloxirane |
| CAS-No.: | 75-56-9 | EC-Index-No.: | 603-055-00-4 | ||
| Molar mass: | 58.08 | EINECS-No.: | 200-879-2 | ||
| Molecular formula: | C3H6O | ||||
| 3. Hazards identification |
| May cause cancer. Extremely flammable. Also harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. |
| 4. First aid measures |
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After inhalation: fresh air. Apply mouth-to-mouth resuscitation or mechanical ventilation if necessary. Summon doctor. After skin contact: Rinse off with polyethylene glycol 400. Rewash with plenty of water. Immediately remove contaminated clothing. After eye contact: rinse out with plenty of water for at least 10 minutes with the eyelid held wide open. Immediately summon eye specialist. After swallowing: make victim drink plenty of water, induce vomiting. Immediately summon doctor. |
| 5. Fire-fighting measures |
| Suitable extinguishing media: |
| CO2, powder. Fire extinguisher: carbon dioxide , powder |
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Special risks: |
| Combustible. Vapours heavier than air. Formation of explosible mixtures possible with air. Keep away from sources of ignition. |
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Special protective equipment for fire fighting: |
| Do not stay in dangerous zone without suitable chemical protection clothing and self-contained breathing apparatus. |
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Other information: |
| Take measures to prevent electrostatic charging. Beware of backfiring. |
| 6. Accidental release measures |
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Person-related precautionary measures: Avoid substance contact. Do not inhale vapours/aerosols. Ensure supply of fresh air in enclosed rooms. Procedures for cleaning / absorption: Take up with liquid-absorbent material (e.g. Chemizorb® ). Forward for disposal. Clean up affected area. Environmental-protection measures: Do not allow to enter sewerage system; risk of explosion! |
| 7. Handling and storage |
| Handling: |
| No further requirements. |
| Storage: |
| Tightly closed. In a well-ventilated place. Keep away from sources of ignition and heat. At +15°C to +25°C. Accessible only for authorized persons. |
| 8. Exposure controls/personal protection |
| Personal protective equipment: | |
| Respiratory protection: | required when vapours/aerosols are generated. |
| Eye protection: | required |
| Hand protection: | required |
| Other protective equipment: | Antistatic protective clothing. |
| Industrial hygiene: | Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. Work under hood . Do not inhale substance. Under no circumstances eat or drink at workplace. |
| 9. Physical and chemical properties |
| Form: | liquid | |||
| Colour: | colourless | |||
| Odour: | characteristic | |||
| pH value | not available | |||
| Melting temperature | -112 °C | |||
| Boiling temperature | 34 °C | |||
| Ignition temperature | 430 °C | |||
| Flash point | -37 °C | |||
| Explosion limits | lower | 1.9 Vol% | ||
| upper | 24 Vol% | |||
| Vapour pressure | (20 °C) | 590 mbar | ||
| Density | (20 °C) | 0.83 g/cm3 | ||
| Solubility in | water | (20 °C) | 405 g/l | |
| organic solvents | (20 °C) | soluble |
| 10. Stability and reactivity |
| Conditions to be avoided |
| Heating. |
| Substances to be avoided |
| strong oxidizing agents , ammonia , halogens , polymerization initiators (i.a. alkali hydroxides , alkalis , acids , amines , metallic oxides , metallic chlorides ) |
| Hazardous decomposition products |
| peroxides |
| Further information |
|
highly inflammable ; incompatible with various plastics , rubber , copper ; Explosible with air in a vaporous/gaseous state. |
| 11. Toxicological information |
| Acute toxicity |
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LD50 (oral, rat): 380 mg/kg ; LD50 (dermal, rabbit): 1245 mg/kg ; LC50 (inhalation, rat): 4000 ppm(V) /4 h |
| Subacute to chronic toxicity |
| Animal experiments performed under conditions comparable with the workplace situation have shown the substance to be carcinogenic. |
| Further toxicological information |
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After skin contact: Burns. After eye contact: Burns. Swallowing causes nausea and vomiting. Toxic effect on: liver , kidneys |
| Further data |
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Further hazardous properties cannot be excluded. The product should be handled with the care usual when dealing with chemicals. |
| 12. Ecological information |
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Ecotoxic effects: Biological effects: Toxic for aquatic organisms Toxic effect on fish and plankton. Forms toxic mixtures in water, dilution measures notwithstanding. Risk of formation of explosive vapours above water surface. Fish toxicity: L.idus LC50: 0.1 mg/l /48 h ; C.auratus LC50: 170 mg/l /24 h ; Further ecologic data: Do not allow to enter waters, waste water, or soil! |
| 13. Disposal considerations |
| Product: |
| There are no uniform EC Regulations for the disposal of chemicals or residues. Chemical residues generally count as special waste. The disposal of the latter is regulated in the EC member countries through corresponding laws and regulations. We recommend that you contact either the authorities in charge or approved waste disposal companies which will advise you on how to dispose of special waste. |
| Packaging: |
| Disposal in compliance with official regulations. Handle contaminated packaging in the same way as the substance itself. If not officially specified differently, non-contaminated packaging may be treated like household waste or recycled. |
| 14. Transport information |
| Transport over land ADR/RID and GGVS/GGVE (Germany) | ||||
| GGVS/GGVE class: | 3 | Number and letter: | 2a | |
| ADR/RID class: | 3 | Number and letter: | 2a | |
| Name of material: | 1280 PROPYLENOXID | |||
| River transport ADN/ADNR | |||
| not examined | |||
| Sea transport IMDG | ||||||
| IMDG class: | 3.1 | UN-No.: | 1280 | Packaging group: | I | |
| Ems: | 3-06 | MFAG: | 365 | |||
| Correct technical name: | PROPYLENE OXIDE | |||||
| Air transport ICAO-TI and IATA-DGR | |||||
| ICAO/IATA class: | 3 | UN/ID-No.: | 1280 | Packaging group: | I |
| Correct technical name: | PROPYLENE OXIDE | ||||
| The transport regulations are cited according to international regulations and in the form applicable in Germany (GGVS/GGVE). Possible national deviations in other countries are not considered. |
| 15. Regulatory information |
| Labelling according to EC Directives | ||
| Symbol: | F+ | Extremely flammable immediately and show this container or label. |
| T | Toxic immediately and show this container or label. | |
| R-phrases: | R 45-12-E20/21/22-36/37/38 | May cause cancer. Extremely flammable. Also harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. |
| S-phrases: | S 53-45 | Avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
| EC-No.: | 200-879-2 | EC label |
| German regulations | ||
| Water pollution class | 2 | (polluting substance) |
| 16. Other information |
| Reason for alteration |
|
Change in transport classification. Change in the chapter on toxicology. |
