| Safety data sheet |
| According to EC Directive 91/155/EEC |
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| 1. Identification of the substance/preparation and of the company/undertaking |
| Identification of the product | ||
| Catalogue No.: | 803296 | |
| Product name: | Epichlorohydrine for synthesis | |
| Manufacturer/supplier identification | ||
| Company: |
Merck Ltd. 9th Floor, Monterey Tower, 2170 New Petchburi Road, Bangkapi, Huaykwang, Bangkok 10320 Tel: (662) 308 - 0218 |
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| 2. Composition/information on ingredients |
| Synonyms |
| 1-Chloro-2,3-epoxypropane ; 2,3-Epoxypropyl chloride |
| CAS-No.: | 106-89-8 | EC-Index-No.: | 603-026-00-6 | ||
| Molar mass: | 92.53 | EINECS-No.: | 203-439-8 | ||
| Molecular formula: | C3H5ClO | ||||
| 3. Hazards identification |
| May cause cancer. Flammable. Also toxic by inhalation, in contact with skin and if swallowed. Causes burns. May cause sensitization by skin contact. |
| 4. First aid measures |
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After inhalation: fresh air. If necessary, apply mouth-to-mouth resuscitation or mechanical ventilation. After skin contact: wash off with plenty of water. Dab with polyethylene glycol 400. Immediately remove contaminated clothing. After eye contact: rinse out with plenty of water for at least 10 minutes with the eyelid held wide open. Immediately summon eye specialist. After swallowing: make victim drink plenty of water, avoid vomiting (risk of perforation!). Immediately summon doctor. |
| 5. Fire-fighting measures |
| Suitable extinguishing media: |
| Water, CO2, foam, powder. |
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Special risks: |
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Combustible. Development of hazardous combustion gases or vapours possible in the event of fire. The following may develop in event of fire: hydrochloric acid |
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Special protective equipment for fire fighting: |
| Do not stay in dangerous zone without suitable chemical protection clothing and self-contained breathing apparatus. |
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Other information: |
| Prevent fire-fighting water from entering surface water or groundwater. |
| 6. Accidental release measures |
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Person-related precautionary measures: Do not inhale vapours/aerosols. Avoid substance contact. Ensure supply of fresh air in enclosed rooms. Environmental-protection measures: Do not allow to enter sewerage system. Procedures for cleaning / absorption: Take up with liquid-absorbent material (e.g. Chemizorb® ). Forward for disposal. Clean up affected area. |
| 7. Handling and storage |
| Handling: |
| Keep away from sources of ignition. Take measures to prevent electrostatic charging. |
| Storage: |
| At +15°C to +25°C. Tightly closed in a well-ventilated place, away from sources of ignition and heat. Accessible only for authorized persons. |
| 8. Exposure controls/personal protection |
| Personal protective equipment: | |
| Respiratory protection: | required when vapours/aerosols are generated. |
| Eye protection: | required |
| Hand protection: |
required Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier. |
| Industrial hygiene: | Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. Under no circumstances eat or drink at workplace. Work under hood . Do not inhale substance. |
| 9. Physical and chemical properties |
| Form: | liquid | |||
| Colour: | colourless | |||
| Odour: | pungent | |||
| pH value | not available | |||
| Melting temperature | -48 °C | |||
| Boiling temperature | 116 °C | |||
| Ignition temperature | 416 °C | |||
| Flash point | 26 °C | |||
| Explosion limits | lower | 2.3 Vol% | ||
| upper | 34.4 Vol% | |||
| Vapour pressure | (20 °C) | 16.5 hPa | ||
| Density | (20 °C) | 1.18 g/cm3 | ||
| Solubility in | water | (20 °C) | 66 g/l | |
| organic solvents | (20 °C) | soluble |
| 10. Stability and reactivity |
| Conditions to be avoided |
| no information available |
| Substances to be avoided |
| acids , alkalis , alcohols |
| Hazardous decomposition products |
| no information available |
| Further information |
| Keep away from sources of ignition. |
| 11. Toxicological information |
| Acute toxicity |
|
LD50 (oral, rat): 90 mg/kg LD50 (dermal, rabbit): 515 mg/kg The literature data available to us do not conform with the labelling prescribed by the EC. The EC has dossiers of the manufacturers which have not been published. |
| Subacute to chronic toxicity |
| Animal experiments performed under conditions comparable with the workplace situation have shown the substance to be carcinogenic. |
| Further toxicological information |
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After inhalation: burns After skin contact: burns Danger of skin absorption. After eye contact: Burns. Risk of blindness! After swallowing: burns in mouth, throat, oesophagus and gastrointestinal tract. |
| Further data |
| The product should be handled with the care usual when dealing with chemicals. |
| 12. Ecological information |
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Ecotoxic effects: Quantitative data on the ecological effect of this product are not available. Further ecologic data: Do not allow to enter waters, waste water, or soil! |
| 13. Disposal considerations |
| Product: |
| There are no uniform EC Regulations for the disposal of chemicals or residues. Chemical residues generally count as special waste. The disposal of the latter is regulated in the EC member countries through corresponding laws and regulations. We recommend that you contact either the authorities in charge or approved waste disposal companies which will advise you on how to dispose of special waste. |
| Packaging: |
| Disposal in compliance with official regulations. Handle contaminated packaging in the same way as the substance itself. If not officially specified differently, non-contaminated packaging may be treated like household waste or recycled. |
| 14. Transport information |
| Transport over land ADR/RID and GGVS/GGVE (Germany) | ||||
| GGVS/GGVE class: | 6.1 | Number and letter: | 16b | |
| ADR/RID class: | 6.1 | Number and letter: | 16b | |
| Name of material: | 2023 EPICHLORHYDRIN | |||
| River transport ADN/ADNR | |||
| not examined | |||
| Sea transport IMDG | ||||||
| IMDG class: | 6.1 | UN-No.: | 2023 | Packaging group: | II | |
| Ems: | 6.1-01 | MFAG: | 740 | |||
| Correct technical name: | EPICHLOROHYDRIN | |||||
| Air transport ICAO-TI and IATA-DGR | |||||
| ICAO/IATA class: | 6.1/3 | UN/ID-No.: | 2023 | Packaging group: | |
| Correct technical name: | EPICHLOROHYDRIN - INHAL.-TOX. VERBOTEN | ||||
| The transport regulations are cited according to international regulations and in the form applicable in Germany (GGVS/GGVE). Possible national deviations in other countries are not considered. |
| EXCLUDED FROM TRANSPORT BY AIR! |
| 15. Regulatory information |
| Labelling according to EC Directives | ||
| Symbol: | T | Toxic immediately and show this container or label. |
| R-phrases: | R 45-10-E23/24/25-34-43 | May cause cancer. Flammable. Also toxic by inhalation, in contact with skin and if swallowed. Causes burns. May cause sensitization by skin contact. |
| S-phrases: | S 53-45 | Avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
| EC-No.: | 203-439-8 | EC label |
| German regulations | ||
| Water pollution class | 3 | (highly polluting substance) |
| 16. Other information |
| Reason for alteration |
|
Change in transport classification. General update. |
