| Safety data sheet |
| According to EC Directive 91/155/EEC |
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| 1. Identification of the substance/preparation and of the company/undertaking |
| Identification of the product | ||
| Catalogue No.: | 841607 | |
| Product name: | Acetone cyanohydrin for synthesis | |
| Manufacturer/supplier identification | ||
| Company: |
Merck Ltd. 9th Floor, Monterey Tower, 2170 New Petchburi Road, Bangkapi, Huaykwang, Bangkok 10320 Tel: (662) 308 - 0218 |
|
| 2. Composition/information on ingredients |
| CAS-No.: | 75-86-5 | EC-Index-No.: | 608-004-00-X | ||
| Molar mass: | 85.11 | EINECS-No.: | 200-909-4 | ||
| Molecular formula: | C4H7NO | ||||
| 3. Hazards identification |
| Very toxic by inhalation, in contact with skin and if swallowed. Very toxic to aquatic organisms. |
| 4. First aid measures |
|
After inhalation: fresh air. Immediately summon doctor. After skin contact: wash off with plenty of water. Immediately remove contaminated clothing. After eye contact: rinse out with plenty of water for at least 10 minutes with the eyelid held wide open. Immediately summon eye specialist. After swallowing: make victim drink plenty of water, induce vomiting. Immediately summon doctor. If victim is unconscious: lateral recumbent position. If breathing stops: immediately apply mechanical ventilation, if necessary also oxygen. Keep airways free. First-aid personnel: ensure self-protection! Decomposition products: hydrogen cyanide |
| 5. Fire-fighting measures |
| Suitable extinguishing media: |
| powder Fire extinguisher: powder , carbon dioxide |
|
Special risks: |
| Combustible. Vapours heavier than air. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire. The following may develop in event of fire: nitrogen oxides , hydrogen cyanide |
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Special protective equipment for fire fighting: |
| Do not stay in dangerous zone without suitable chemical protection clothing and self-contained breathing apparatus. |
|
Other information: |
| Cool container with spray water from a save distance. |
| 6. Accidental release measures |
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Person-related precautionary measures: Do not inhale vapours/aerosols. Avoid substance contact. Ensure supply of fresh air in enclosed rooms. Environmental-protection measures: Do not allow to enter sewerage system. Procedures for cleaning / absorption: Take up with liquid-absorbent material (e.g. Chemizorb® ). Forward for disposal. Clean up affected area. |
| 7. Handling and storage |
| Handling: |
|
Notes for safe handling: Ensure adequate exhaustion and ventilation. Do not feed back exhausted air into working areas. |
| Storage: |
| Cool (below +15°C). Tightly closed in a well-ventilated place. Accesible only for authorised persons. |
| 8. Exposure controls/personal protection |
| Personal protective equipment: | |
| Respiratory protection: | required when vapours/aerosols are generated. |
| Eye protection: | required |
| Hand protection: |
required Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier. |
| Industrial hygiene: | Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. Under no circumstances eat or drink at workplace. Work under hood . Do not inhale substance. |
| 9. Physical and chemical properties |
| Form: | liquid | |||
| Colour: | yellow | |||
| Odour: | bitter almond-like | |||
| pH value | not available | |||
| Melting temperature | -19 °C | |||
| Boiling temperature | 82 °C | |||
| Ignition temperature | 687 °C | |||
| Flash point | 75 °C | |||
| Explosion limits | lower | 2.2 Vol% | ||
| upper | 12 Vol% | |||
| Vapour pressure | (20 °C) | 0.8 mmHg | ||
| Relative vapour density_ | (95 °C) | 2.93 | ||
| Density | (20 °C) | 0.932 g/cm3 |
| 10. Stability and reactivity |
| Conditions to be avoided |
| no information available |
| Substances to be avoided |
| oxidizing agent , sulfuric acid |
| Hazardous decomposition products |
| hydrogen cyanide |
| Stabilizer |
| sulfuric acid |
| Further information |
| sensitive to moisture |
| 11. Toxicological information |
| Acute toxicity |
|
LD50 (oral, rat): 18.6 mg/kg LD50 (dermal, rabbit): 16 mg/kg |
| Further toxicological information |
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After inhalation: Irritations of the mucous membranes, coughing, and dyspnoea. After skin contact: Irritations Danger of skin absorption. After eye contact: Severe irritations. After swallowing: irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract. The following applies to cyanogen compounds/ nitriles in general: utmost caution! Release of hydrocyanic acid is possible - blockade of cellular respiration. Cardiovascular disorders, dyspnoea, unconsciousness. Systemic effects: headache , confusion , Nausea, vomiting |
| Further data |
| The product should be handled with the care usual when dealing with chemicals. |
| 12. Ecological information |
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Ecotoxic effects: Quantitative data on the ecological effect of this product are not available. Further ecologic data: Do not allow to enter waters, waste water, or soil! |
| 13. Disposal considerations |
| Product: |
| There are no uniform EC Regulations for the disposal of chemicals or residues. Chemical residues generally count as special waste. The disposal of the latter is regulated in the EC member countries through corresponding laws and regulations. We recommend that you contact either the authorities in charge or approved waste disposal companies which will advise you on how to dispose of special waste. |
| Packaging: |
| Disposal in compliance with official regulations. Handle contaminated packaging in the same way as the substance itself. If not officially specified differently, non-contaminated packaging may be treated like household waste or recycled. |
| 14. Transport information |
| Transport over land ADR/RID and GGVS/GGVE (Germany) | ||||
| GGVS/GGVE class: | 6.1 | Number and letter: | 11a | |
| ADR/RID class: | 6.1 | Number and letter: | 11a | |
| Name of material: | 1541 ACETONCYANHYDRIN, STABILISIERT | |||
| River transport ADN/ADNR | |||
| not examined | |||
| Sea transport IMDG | ||||||
| IMDG class: | 6.1 | UN-No.: | 1541 | Packaging group: | I | |
| Ems: | 6.1-02 | MFAG: | 215 | |||
| Correct technical name: | ACETONE CYANOHYDRIN,STABILIZED - MARINE POLLUTANT | |||||
| Air transport ICAO-TI and IATA-DGR | |||||
| ICAO/IATA class: | 6.1 | UN/ID-No.: | 1541 | Packaging group: | |
| Correct technical name: | ACETONE CYANOHYDRIN,STABILIZED - VERBOTEN | ||||
| The transport regulations are cited according to international regulations and in the form applicable in Germany (GGVS/GGVE). Possible national deviations in other countries are not considered. |
| 15. Regulatory information |
| Labelling according to EC Directives | ||
| Symbol: | T+ | Very toxic immediately and show this container or label. |
| N | Dangerous for the environment immediately and show this container or label. | |
| R-phrases: | R 26/27/28-50 | Very toxic by inhalation, in contact with skin and if swallowed. Very toxic to aquatic organisms. |
| S-phrases: | S 7/9-27-45-61 | Keep container tightly closed and in a well-ventilated place. Take off immediately all contaminated clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid release to the environment. Refer to special instructions/Safety data sheets. |
| EC-No.: | 200-909-4 | EC label |
| German regulations | ||
| Water pollution class | 3 | (highly polluting substance) |
| 16. Other information |
| no information available |
